| Key Points from this Post (aka TLDR 😊) – GLP-1 weight loss medications can cause digestive discomfort due to slowed digestion. – Taking digestive enzymes while on Zepbound may help alleviate these side effects by aiding food breakdown. I personally take MassZymes. – Consulting a doctor is essential before taking any supplements, especially with these medications. |
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Okay, let’s talk about something that’s been on my mind lately, and I know many of you might be experiencing it too: the digestive side effects of GLP-1 medications like Zepbound.
I’ve been researching how digestive enzymes might help alleviate some of the discomfort associated with these medications, and I wanted to share what I’ve learned. I want to share what I have learned and the digestive enzymes I am currently taking.
Understanding GLP-1s and Digestion
GLP-1 agonists, like Zepbound (tirzepatide), work by mimicking a natural hormone that helps regulate blood sugar and slows down gastric emptying. This slower digestion contributes to the feelings of fullness that aid in weight loss. However, this slowed process can also lead to some uncomfortable side effects, such as:
- Stomach pain and abdominal pain: The delayed emptying can cause food to sit in the stomach longer, leading to discomfort.
- Slow digestion and digestive issues: Many experience bloating, gas, and general digestive unease.
- Potential for food intolerance symptoms: Because food stays in the system longer, some people may start to notice sensitivities that they previously did not.
These side effects are common, and while they often subside as your body adjusts, they can significantly impact your quality of life. It’s important to remember that these medications are relatively new, and biomedical researchers and scientific collaborations are continually working to understand the full scope of their effects.
How Taking Digestive Enzymes while on Zepbound Can Help
This is where digestive enzymes come in. These are proteins that help break down food into smaller, more easily absorbed nutrients. The main enzymes involved in digestion are:
- Amylase: Breaks down carbohydrates.
- Protease: Breaks down proteins.
- Lipase: Breaks down fats.
By supplementing with these enzymes, you can support your body’s natural digestive process, potentially easing some of the discomfort caused by slowed gastric emptying.
Here’s how they can help:
- Improved digestion: Digestive enzyme supplements can aid in breaking down food more efficiently, reducing bloating and gas.
- Reduced stomach pain: By helping to break down food more quickly, these enzymes can lessen the burden on the stomach, potentially reducing abdominal pain.
- Support for digestive health: Maintaining healthy digestion is crucial, especially when taking medications that affect the digestive system.
It’s important to note that digestive enzyme supplements are different from lipase inhibitors like orlistat. Lipase inhibitors work by preventing the absorption of dietary fats, which can lead to other digestive side effects. Digestive enzyme supplements, on the other hand, support the breakdown of food.
My Personal Choice for Digestive Enzymes while on Zepbound: MassZymes

- MassZymes is a full-spectrum digestive enzyme supplement:
- It contains a variety of enzymes (like protease, lipase, amylase, etc.) designed to break down proteins, fats, and carbohydrates.
- It is designed to aid in the digestion process.
- Improved Nutrient Absorption:
- By enhancing digestion, MassZymes helps the body absorb nutrients more efficiently.
- Better nutrient absorption can combat deficiencies that lead to fatigue.
- Reduced Digestive Burden:
- When digestion is inefficient, the body expends significant energy on the process.
- MassZymes reduces this burden, freeing up energy for other functions.
- Combating Inflammation:
- Incomplete digestion can trigger inflammation, which saps energy.
- By promoting thorough digestion, MassZymes may help reduce inflammation.
- How it helps with energy levels:
- By helping to break down food more effectively, it allows the body to absorb more nutrients from the food that is eaten. Nutrients are what give the body energy.
- By easing the bodies digestive process, the body is able to use energy that would have been used for digestion, for other bodily functions.
- By aiding in the reduction of inflammation, more energy is preserved.
- In essence, MassZymes aims to optimize digestion, which in turn can lead to improved nutrient absorption, reduced energy expenditure on digestion, and potentially decreased inflammation, all of which can contribute to increased energy levels. Always talk to your healthcare provider before starting on any new supplements.
Important Considerations when Choosing Digestive Enzymes while on Zepbound
While digestive enzyme supplements can be beneficial, it’s crucial to consult your healthcare provider or prescribing provider before taking them. They can help you determine if they are appropriate for your individual needs and rule out any potential adverse reactions or risk factors, such as bowel obstruction, which, while rare, is a serious concern.
Here are some points to keep in mind:
- Individual responses vary: What works for one person may not work for another.
- Quality matters: Choose high-quality digestive enzyme supplements from reputable brands.
- Probiotic supplement support: Some people find that combining digestive enzymes with a probiotic supplement can further enhance digestive health. Probiotics help maintain a healthy balance of gut bacteria, which is essential for optimal digestion.
- Food intolerance: If you suspect you have developed a new food intolerance, please speak to your doctor.
- Diabetic retinopathy: If you are also treating diabetic retinopathy, it is especially important to speak to your prescribing provider.
- Severe pain: If you experience severe pain, please seek medical attention immediately.
A Personal Perspective
As someone navigating the complexities of weight management and aging, I understand the desire for solutions that improve our well-being. I’ve found that open communication with my healthcare provider and thorough research have been invaluable. I believe in taking a holistic approach to health, which includes addressing not only weight loss but also the digestive health that supports it.
It’s also important to remember that the fields of evolutionary biology, including the work of evolutionary biologists, can help us understand how our bodies have adapted and how modern diets and medications can affect those adaptations. While this is a complex subject, it highlights the importance of understanding our bodies and how they function.
The FDA approval of medications like Zepbound represents significant progress in weight management. However, it’s equally important to address the side effects that can accompany these medications. By exploring options like digestive enzyme supplements, we can empower ourselves to take control of our digestive health and improve our overall quality of life.
Remember, you’re not alone in this journey. We all deserve to feel our best, and by working together with our healthcare providers, we can find the solutions that work for us.
Sources:
- Give the Receptor a Brake: Slowing Gastric Emptying by GLP-1 | Diabetes | American Diabetes Association
- 10 GLP-1 Side Effects You Should Know About – GoodRx
- GLP-1 Medications: Benefits, Side Effects and Success Tips | Ochsner Health
- Research shows GLP-1 drugs are effective but complex – UChicago Medicine
- Physiology, Digestion – StatPearls – NCBI Bookshelf

Disclaimers: Friends, I am not a medical professional, nor do I pretend to be one on the internet. This information is for educational purposes only, gathered from trusted sources and my personal experiences. Always consult with your healthcare provider before making any changes to your medication or lifestyle. This post has links included that are affiliate links. Countess of Shopping & her furbabies will be compensated when you make a purchase by clicking through the links at no cost to you. As an Amazon Associate I earn from qualifying purchases. This post is sponsored by BIOptimizers.




